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Can letrozole cause miscarriage? There is no evidence that letrozole is connected to early miscarriages in any way. The main cause of miscarriage in the first trimester is chromosomal abnormalities in the embryo. If you suffer from recurrent miscarriages it may be helpful to look into additional testing for the uterine lining as well as genetic testing for embryos. These tests are the best way to help minimize the chance of miscarriage in early pregnancy. | New Hope Fertility Center

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