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SOLVED: 142 Valine replaces glutamic acid in the hemoglobin of people who have sickle-cell anemia. Is this a change in the primary, secondary, tertiary, Or quaternary structure? Why does this small change affect the shape of the entire protein? Would this change in amino acid sequence affect the secondary, tertiary, or quaternary structure of hemoglobin? Explain how the difference in these two residues might impact how the protein folds.
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