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Cardiac effects of nitroglycerin
Primary Effect: Reduces myocardial oxygen demand mainly by decreasing left ventricular preload Key Mechanisms: Vasodilation: - Preferentially dilates venules (low doses) - Dilates arterioles at higher doses - Dilates coronary arteries (both normal and post-stenotic) Cardiovascular Effects: - Decreases preload → Reduces LV wall stress ...
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