Indianapolis police announce the arrests of a man and woman for the tragic death of an 8-year-old girl who ingested fentanyl ...

A Hamilton County veteran and airline pilot served alongside one of the pilots who lost their lives in a midair collision in Arlington, Virginia.

Celebrate the heroic 1925 'Great Race of Mercy' as Nome honors its saviors, the sled dogs and mushers, who delivered life-saving serum through harsh conditions.

Discover the latest trends in the business world, from Barnes and Noble's growth fueled by BookTok to the FDA's approval of a new nonopioid pain medication.

Japanese authorities urge evacuation as a massive sinkhole in Saitama grows, hampering rescue efforts to free an elderly truck driver.

A new Indiana Office of School Safety prioritized in Gov. Mike Braun’s first-term agenda was pitched by lawmakers Thursday as ...

Hamas announces the release of an American dual national and the father of the youngest hostages from Israel, as part of the ongoing truce negotiations.

Indiana's State Board of Education is set to build a new A-F grading system for schools, which will take into account various factors beyond academic performance, with the aim of providing actionable ...

Tragedy strikes as American Airlines flight and US Army Black Hawk helicopter collide, killing all 67 people on board.

FDA approves new pain pill Journavx, a non-opioid alternative to treat acute pain. Despite modest effectiveness, it shows promise in pain management.

Indianapolis Department of Public Works fills 13,000 potholes in first two days of a three-day blitz, taking advantage of mild weather.

A 42-year-old man is suspected of setting fire to an emergency box at a crisis diversion center in Bloomington, Indiana. He potentially faces a felony charge.