The Seattle Seahawks will visit the San Francisco 49ers in a key game in the NFC West race with both teams trying to catch ...

Star pass-catcher George Kittle and the San Francisco 49ers face the Seattle Seahawks on Sunday at 4:05 p.m. ET, at Levi’s ...

Deebo Samuel revealed why San Francisco quarterback Brock Purdy was upset after Sunday's win over the Tampa Bay Buccaneers.

The San Francisco 49ers have a new weekly problem to solve now that running back Christian McCaffrey has returned from ...

Tampa Bay Buccaneers Tackle Luke Goedeke was mic'd up for Week 10's Salute to Service game against the San Francisco 49ers. Hear from Luke in this week's edition of Mic'd Up.

Cade Otton is showing the rest of the NFL the type of offensive weapon the Tampa Bay Buccaneers always felt he could become.

The San Francisco 49ers earned a hard-fought victory on Sunday against the Tampa Bay Buccaneers, securing back-to-back wins ...

The San Francisco 49ers have another important division game on Sunday, but they may have to play without two of their biggest stars.

Trent Williams missed his second practice in a row on Thursday with an ankle injury. He also sat on Wednesday, but his absence flew under the radar because ...

Asked how it must have felt for Moody to go from the 49ers' biggest loser to the hero of the show, Kyle Shanahan broke down ...

This did not escape two of Mayfield's big media fans, Fox sideline reporter Erin Andrews and studio host Charissa Thompson.

Moody was a controversial selection when the 49ers picked him--a third-rounder is an extraordinarily high pick to use on a ...