Amyloid-related imaging abnormalities, aka ARIA, are red flags on MRI scans. They alert clinicians that a patient on lecanemab or donanemab may be in danger. Yet early signs of ARIA can be subtle and ...
This noninvasive approach attempts to modulate the noradrenergic system of the locus coeruleus by stimulating the vagal nerve. It uses electrodes clipped on the outer ear to stimulate the auricular ...
Scientists have attempted to bolster microglia in the Alzheimer’s brain by switching on TREM2 signaling, but so far, these efforts have met with little success. Might it work better to bypass TREM2 by ...
R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers. This knock-in rat model carries the R47H mutation in the rat Trem2 gene and a humanized Aβ ...
To create this model, an adeno-associated viral (AAV) vector encoding human tau with the P301L mutation was injected into the ventricles of neonatal mice. At 6 months of age, Tau P301L-AAV mice ...
News Peptide Brace Against AD—Insulin, Neuropeptide Y Tame Aβ Toxicity 10 Feb 2009 Aβ and Phospho-tau: Strange Bedfellows Get Intimate at Synapses 19 Sep 2008 The Skinny on FAT: APP’s Role in Fast ...
neuronal cell bodies, dendrites and some thick axonsin the central and peripheral nervous systems, but not thin axons;reflects extent of aberrant phosphorylation of neurofilaments in ...
This mouse model of ALS overexpresses wild-type human TARDBP (TDP-43) in postnatal neurons. Mice in this line, called TAR4, develop ALS-related phenotypes, including severe motor impairment, loss of ...
The purpose of this notice is to inform potential applicants of a change in the key dates for notice of funding opportunity (NOFO) RFA-NS-25-017, BRAIN Initiative: Optimization of Instrumentation and ...
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