Signaling pathway may help predict immunotherapy response in glioblastoma

Northwestern Medicine scientists have uncovered a biological mechanism that helps explain why most patients with glioblastoma ...

Oral Pathway Inhibition Outperforms Traditional Histiocytosis Chemotherapy

Clinical trials show targeted kinase inhibitors provide high response rates in children with refractory histiocytic disorders ...

Clinical Tolerability Profiles Examined for Targeted AKT Inhibition in Metastatic Disease

Clinicians report that early AKT inhibition side effects are manageable, allowing four out of five patients to maintain ...
EurekAlert!

Study reveals first drug-like molecules that control key cellular signaling proteins

Illustration of small molecule modulation of β-arrestins and GPCR signaling pathways based on concepts developed by the Lefkowitz Laboratory, Duke University. To function normally, nearly every cell ...
News-Medical.Net

New generation approaches revive BET protein inhibitors in solid tumors

BET proteins, especially BRD4, drive oncogenic transcription in solid tumours. First‑generation inhibitors (JQ1, molibresib, ...
Frontiers

Immune Checkpoint Inhibitors in Cancer Therapy: Balancing Anti-tumor Immunity, Autoimmunity, and Immune-related Adverse Events, Volume II

Cancer immunotherapy has revolutionized oncology, with immune checkpoint inhibitors (ICIs) becoming integral components of modern anti-cancer treatment ...