Combination of growth factor gene-enhanced cartilage matrix synthesis with interleukin-1 receptor antagonist protein (IL-1Ra) abrogation of cartilage matrix degradation may reduce and possibly reverse ...

A working group develops strategies for regeneration of articular cartilage and has found that natural cartilage matrix is suitable as a biomaterial for improved cartilage regeneration. Just a few ...

Current intra-articular drug delivery methods do not guarantee sufficient drug penetration into cartilage tissue to reach cell and matrix targets at the concentrations necessary to elicit the desired ...

Recently, a research team from Chongqing Medical University, led by Prof. Wei Huang, Dr. Wei Bao, and Dr. Yiting Lei, has successfully developed a novel engineered extracellular matrix (eECM) to ...

In patients with severe osteoarthritis, cartilage can wear so thin that joints essentially transform into bone on bone — without a cushion between. A new therapy that uses synthetic nanofibers to ...

Sox9, a master regulator of cartilage formation, switches its target genes dynamically during embryonic limb development instead of following a fixed program, as reported by researchers from Science ...

Cartilage injuries are a common clinical issue, often caused by trauma, severe infections, or degenerative joint diseases. The lack of direct blood supply to cartilage and limited access to nutrients ...

Northwestern University scientists have developed a new bioactive material that successfully regenerated high-quality cartilage in the knee joints of a large-animal model. Although it looks like a ...

Researchers in Lithuania have found that extracellular vesicles from menstrual blood-derived cells may help regenerate cartilage in osteoarthritis, even in older patients. Lab tests showed these ...

Lithuanian researchers have found that extracellular vesicles from menstrual blood-derived stromal cells can stimulate cartilage repair in osteoarthritis samples, including from postmenopausal women.

An origami scaffold uses electrical repair cues and light-triggered heating to promote cartilage formation while limiting ...

Cartilage cells generate more protein components (collagen II and aggrecan) for regeneration when treated with fast-moving dancing molecules (left) compared to slower moving molecules. In November ...