Figure 1: Chemical reactions of DNA polymerization and ATP-mediated pyrophosphorolytic excision catalyzed by HIV-1 reverse transcriptase (RT). Figure 2: Binding of AZTppppA′ to AZTr HIV-1 reverse ...
HIV-1 reverse transcriptase inhibitors remain a cornerstone of antiretroviral therapy, targeting the enzyme responsible for converting viral RNA into DNA. This class of drugs, particularly nucleoside ...
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