The infection of human immunology viruses (HIV) occurs by integrating its genome into infected cells to enter an inactive state of reversible latency that evades anti-retroviral therapy. The capacity ...

HIV/AIDS remains a major health threat despite significant advances in the prevention and treatment of HIV infection. The major reason is the inability of existing treatments to eradicate the multiple ...

Antiretroviral therapy (ART) effectively suppresses HIV viral load and controls disease, but does not fully eradicate latent HIV. Transcriptionally silent proviruses integrate in CD4+ T cells and ...

Due to the 4-hour maturation half-life of the Timer protein's blue-to-red chromophore, we can detect reactivated or recently silenced proviruses with high sensitivity using Timer fluorescence.

Kumamoto University researchers have developed a novel viral reporter system named HIV-Tocky (Timer of Cell Kinetics and Activity). This innovative system allows for real-time visualization of HIV ...