Cancer cells employ interconnected mechanisms to withstand intrinsic and extrinsic stress, with mutant p53 (mutp53) playing a key role in bolstering resistance to endoplasmic reticulum (ER) stress. In ...
In mammalian cells, the transport of proteins between the nucleus and the cytoplasm plays a critical role in maintaining cellular homeostasis and regulating cell survival and death 1. Aberrant ...
This review illustrates how the nuclear phosphoinositide-p53 signalosome integrates lipid signaling and p53 function to regulate cancer cell motility. The figure contrasts the tumor-suppressive ...
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