Thanks in part to LL Cool J ‘s “Mama Said Knock You Out,” Pfizer’s new Super Bowl commercial will leave viewers feeling hyped about the medical company’s ongoing cancer research — but because of the inspiring message at its center, it’ll also likely leave you in tears.

Picking up from where last year's Big Game ad debut left off, Pfizer wants to bring a note of resilience and motivation to those fighting cancer in its Super Bowl 59 spot. In the ad, a young boy gets out of his hospital bed,

Pfizer is again shining a spotlight on its oncology treatments with its second consecutive Super Bowl ad, a 60-second commercial that will air in the first quarter of the game on Sunday. The ad begins with a young boy in a hospital bed watching announcer Michael Buffer on TV.