During sexual reproduction, haploid gametes (i.e. eggs and sperm) are generated from diploid precursors through the specialized cell division of meiosis. Meiosis reduces ploidy by following one round ...
In the choreography of meiosis—the process responsible for sex cell division in all eukaryotic life—the pairing of homologous chromosomes (homologs) is essential. Errors in this process can lead to an ...
During prophase I of meiosis, chromosomes become organized as loop arrays around the proteinaceous chromosome axis. As homologous chromosomes physically pair and recombine, the chromosome axis is ...
DLGAP5 is proposed as a causal gene related to oocyte meiosis disorder for the first time. It expanded the current spectrum of pathogenic genes responsible for the phenotype of oocyte maturation and ...
Studying over 100,000 embryos revealed genetic factors behind chromosome segregation issues that lead to aneuploidy, ...
Researchers from Johns Hopkins University and the University of Copenhagen analyzed over 139,000 embryos and identified variants in key meiosis genes, such as SMC1B, that influence chromosomal ...
The findings shed new light on human reproduction and suggest pathways for developing treatments to lower the risk of ...
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