This is a preview. Log in through your library . Abstract The cAMP receptor requires cAMP for DNA binding at pH 8.0 but shows cAMP-independent DNA binding at pH 6.0. Incubation of the cAMP receptor ...

Makoff, R., Roberts, S., and Fowler, D. D., J. Biol. Chem. (in the press). Makoff, R., and Roberts, S., Biochim. Biophys. Acta (in the press). Grant, J. K., in ACTH ...

Cytotoxic, apoptotic and molecular effects of fucoidan as single agent and in combination with trastuzumab and docetaxel in HER2(+) breast cancer cells.

The well-known second messenger cyclic adenosine 3′-5′-monophosphate (cAMP) plays a central role in the cells response to external stimuli. While the regulation of cAMP can be controlled by a number ...

G-protein coupled receptors (GPCRs) are a major class of targets for drug discovery. Cyclic AMP (cyclic adenosine 3′,5′-monophosphate) is a second messenger and one of the most important intracellular ...

Cyclic dinucleotides (CDNs) are secondary messengers used by prokaryotic and eukaryotic cells. In mammalian cells, cytosolic CDNs bind STING (stimulator of IFN gene), resulting in the production of ...

Adenosine is a short-acting endogenous molecule that is a purine nucleoside. The half-life is 6 seconds. Adenosine receptor activation results in multiple different actions depending on the location.

Adenosine kinase is an important enzyme that regulates both the intracellular and extracellular concentrations of adenosine. The inhibition of this enzyme has numerous clinical applications ranging ...