Researchers identify beta catenin protein degradation as a therapeutic vulnerability in B cell acute lymphoblastic leukaemia, supporting the repurposing of glycogen synthase kinase 3 beta inhibitors.
The C-Jun N-Terminal Kinase (JNK) signalling pathway plays a pivotal role in regulating cellular responses to stress and damage. As a member of the mitogen-activated protein kinase (MAPK) family, JNK ...
A preclinical study has reported that simultaneous inhibition of cyclin-dependent kinases 2 and 4/6 produced durable tumour ...
Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...
Mantle cell lymphoma (MCL) represents a relatively uncommon, heterogeneous lymphoma associated with limited overall survival. Targeting of the B-cell receptor pathway in relapsed disease with covalent ...
The mitogen-activated protein kinase (MAPK) pathway integrates growth factor signaling through extracellular signal-regulated kinase (ERK) to control cell proliferation. To study ERK dynamics, many ...
The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.
Researchers have identified beta (β) catenin degradation as a critical and previously unrecognised vulnerability in B cell ...
Stressed brain cells can survive longer by slowing sugar use, revealing a short-term protective response that later turns ...
Mantle cell lymphoma (MCL) represents a relatively uncommon, heterogeneous lymphoma associated with limited overall survival. Targeting of the B-cell receptor pathway in relapsed disease with covalent ...
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