High-risk myelodysplastic syndrome, a bone marrow cancer that can turn into acute myeloid leukemia, is driven by stem cells that burn through an unusually large supply of one molecule: nicotinamide ...

High-risk MDS stem cells appear to have an unexpected “energy addiction,” relying far more heavily than healthy blood-forming cells on a molecule called NAD. Disrupting this energy pathway selectively ...

A protein known as p53 is, of all tumor suppressors in human cancer, the most frequently altered by gene mutations. When ...

The spread of cancer from a primary tumor to another place in the body, called metastasis, remains one of the greatest ...

A hallmark of cancerous cells is an abnormal number of chromosomes or chromosome arms, known as aneuploidy. While aneuploidy is detrimental to regular cells, it occurs in as many as 90% of tumors. How ...

Researchers have created the first stable prostate cancer cell lines resistant to blood-flow-level shear stress and ...

Mount Sinai team finds that loss of p53 can also change how growth and tissue development signals are organized across a ...