It's going to be a very busy spring, summer, and fall for Lionel Messi and Inter Miami, who are led by Javier Mascherano in their defense of the Supporters' Shield and quest for a first MLS Cup.

Lionel Messi was in the starting lineup for Inter Miami’s MLS season opener against NYCFC Saturday night, 72 hours after scoring the lone goal in a Concacaf Champions Cup win at Sporting KC in frigid weather conditions. It was a balmy 68 degrees for the MLS game at Chase Stadium, much more comfortable for Messi and his teammates.

From who will win the league to if Lionel Messi can go back to back as MVP, there's no such thing as a new season without predictions to look back on that can go horribly wrong in this unpredictable league.