Holger Rune has yet to lose a set at the Madrid Masters. The Norwegian faced Daniil Medvedev in the quarter-final and earned a 6-3, 7-5 victory in an hour and 40 minutes. Thus, Casper earned his first victory over Daniil and reached his ninth Masters 1000 semi-final.

Since the ATP Masters 1000 format was introduced in 1990, Casper Ruud is just the third player to win each of his first seven quarter-finals on clay, after Guillermo Coria and Rafael Nadal

Daniil Medvedev and Casper Ruud are through to the quarterfinals of the 2025 Madrid Open, alongside Jack Draper, Matteo Arnaldi, Jakub Mensik, and Francisco Cerundolo.