Stem Cells for Huntington's Disease (SC4HD): An International
WEBTechnological advances to direct the differentiation of stem cells to desired neural types have opened new strategies for restoring damaged neuronal circuits in HD. However, challenges remain in the implementation of cell therapy …
Stem Cells for Huntington’s Disease (SC4HD): An International ...
WEBJun 9, 2021 · The overall goal of the SC4HD consortium is to define the challenges to be addressed across the spectrum of cell manufacturing, preclinical assessments and clinical application, to enable the promise of stem cell-based therapies to be transplanted in the brain for treatment of HD.
Huntington’s disease: how could stem cells help? | Eurostemcell
WEBJun 30, 2016 · Huntington’s Disease (HD) mainly affects nerve cells in the brain called medium spiny neurons (MSNs). MSNs receive and coordinate information from other neurons in the brain to control movement, intellectual processes and emotion.
Advances in stem cell and other therapies for ... - ScienceDirect
WEBJul 1, 2023 · Stem cell research as a treatment for HD has included the use of various types of stem cells, such as mesenchymal stem cells, neural stem cells, embryonic stem cells, and even reprogrammed stem cells called induced pluripotent stem cells.
Regenerative Stem Cell Therapy for Neurodegenerative Diseases…
WEBFeb 22, 2021 · Stem cell therapy, also known as regenerative therapy, improves the repair response of dysfunctional and damaged tissue using stem cells or their derivatives. The objectives of stem cell therapies typically focus either on cellular replacement or on providing environmental enrichment.
Stem Cells Highlighted as Potential Therapeutic Option in ... - AJMC
WEBOct 15, 2022 · “Hence, stem cell therapy can be a flourishing therapeutic strategy as a targeted approach to replace the dysfunctional cells in HD.” The review highlights MSCs, iPSCs, ESCs, and NSCs as...
Mesenchymal Stem Cell Therapy for Huntington Disease: A Meta …
WEBApr 30, 2023 · Mesenchymal stem cell (MSC) therapy has been explored in Huntington disease (HD) as a potential therapeutic approach; however, a complete synthesis of these results is lacking. We conducted a meta-analysis to evaluate the effects of MSCs on HD.
Advances in stem cell and other therapies for Huntington's
WEBStem cell research as a treatment for HD has included the use of various types of stem cells, such as mesenchymal stem cells, neural stem cells, embryonic stem cells, and even reprogrammed stem cells called induced pluripotent stem cells.
Induced Pluripotent Stem Cells from Patients with Huntington's …
WEBAug 3, 2012 · Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded stretch of CAG trinucleotide repeats that results in neuronal dysfunction and death. Here, The HD Consortium reports the generation and characterization of 14 induced pluripotent stem cell (iPSC) lines …
Concise Review: The Use of Stem Cells for ... - Oxford Academic
WEBDec 5, 2017 · Stem cells play an important role to enhance our understanding and treatment of Huntington's disease (HD). This review discusses the role of (a) compensatory neurogenesis in the HD brain, (b) the use of stem cell-based therapies for HD to replace or prevent cell loss, and (c, d) advances in cell reprogramming to model and/or treat HD.